Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents
Related Experiment Video
Updated: May 27, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
Published on: July 11, 2025
Annie Mayence1, Jean Jacques Vanden Eynde, Marcel Kaiser
1Xavier University of Louisiana, College of Pharmacy, Division of Basic Pharmaceutical Sciences, 1 Drexel drive, New Orleans, LA 70125, USA.
Abstract:
A small library of 26 2,2'-[alkane-α,ω-diylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and evaluated against Giardia intestinalis, Entamoeba histolytica, Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum. Among the tested compounds, eight derivatives (17, 19, 20, 24, 27, 30, 32 and 35) exhibited an anti-Plasmodium falciparum activity characterized by IC(50) values in the range of 180-410 nM (0.11-0.21 μg/mL) and selectivity indexes (IC(50) rat skeletal myoblasts L6 cells vs IC(50)P. falciparum K1 strain) varying between 92 and more than 450. Two of the eight novel drug leads, namely compounds 19 and 32, were also active against G. intestinalis and L. donovani with selectivity indexes of 122 and >164 respectively.
Related Concept Videos
Anthelminthic Agents
Antiprotozoal Agents
Malaria
Antifungal Agents
Aryldiazonium Salts to Azo Dyes: Diazo Coupling

