[Modulation of pancreatic chymotrypsin messenger RNA during post-natal development and weaning in calves]

Levels of chymotrypsin mRNA in the pancreatic tissue of preruminant calves were significantly decreased on d 28 and to a lesser extent on d 119 as compared to those of newborns. Enzymic activity regularly increased during the same period. By contrast, both chymotrypsin-specific activity and the mRNA level in the ruminant animals were enhanced on d 119 (1.4- and 2.3-fold, respectively), suggesting that some pretranslational regulation of the chymotrypsin gene was induced by weaning.