Related Experiment Video

Updated: May 27, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

Tumor angiogenesis: molecular pathways and therapeutic targets

Sara M Weis1, David A Cheresh

  • 1Department of Pathology and Moores University of California-San Diego Cancer Center, University of California-San Diego, La Jolla, California, USA.

Nature Medicine
|November 9, 2011
PubMed

Insights

Controlling tumor angiogenesis is key to limiting cancer spread. Targeting multiple tumor microenvironment aspects is necessary for effective anti-cancer therapies.

Area of Science:

  • Oncology
  • Cancer Biology
  • Tumor Microenvironment

Background:

  • Angiogenesis, the formation of new blood vessels, is crucial for tumor growth and metastasis.
  • The tumor microenvironment contains signaling molecules and pathways that regulate angiogenesis.
  • Understanding these interactions is vital for developing new cancer therapies.

Purpose of the Study:

  • To explore the role of the tumor microenvironment in regulating angiogenesis.
  • To identify mechanisms of resistance to anti-angiogenic therapies.
  • To inform the development of novel therapeutic strategies targeting tumor angiogenesis.

Main Methods:

  • Review of current literature on tumor angiogenesis and the tumor microenvironment.
  • Analysis of signaling pathways involved in angiogenic stimulation and repression.
  • Examination of resistance mechanisms in anti-angiogenic therapy.

Main Results:

  • Tumor-associated angiogenesis is a complex process influenced by multiple factors within the tumor microenvironment.
  • Various signaling molecules act as either stimuli or repressors of angiogenesis.
  • Mechanisms of resistance to anti-angiogenic therapies are multifaceted and require further investigation.

Conclusions:

  • Effective control of tumor angiogenesis requires a comprehensive understanding of the tumor microenvironment.
  • Simultaneous or sequential targeting of multiple pathways is essential for durable anti-angiogenic responses.
  • Future therapeutic strategies should focus on combination approaches to overcome resistance and enhance efficacy.

More Related Videos

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis09:33

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Published on: March 20, 2026

Isolation and Culture Expansion of Tumor-specific Endothelial Cells10:15

Isolation and Culture Expansion of Tumor-specific Endothelial Cells

Published on: October 14, 2015

Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...