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Stem cells and the vasculature

Victoria L Bautch1

  • 1Department of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. bautch@med.unc.edu

Nature Medicine
|November 9, 2011
PubMed

Insights

Stem and progenitor cells are crucial for blood vessel formation and function. This review explores their reciprocal roles in development, disease, and the creation of stem cell niches.

Area of Science:

  • Vascular Biology
  • Stem Cell Research
  • Regenerative Medicine

Background:

  • The interplay between stem/progenitor cells and blood vessels is a key area in vascular research.
  • Significant controversies exist regarding these relationships.

Purpose of the Study:

  • To review the contributions of vascular stem and progenitor cells to vascular and nonvascular lineages.
  • To explore how nonvascular stem cells may form vascular lineages.
  • To discuss the role of vasculature in stem cell niche formation.

Main Methods:

  • Literature review of recent advancements in vascular and stem cell research.
  • Synthesis of findings on cell contributions and niche formation.
  • Analysis of disease implications and therapeutic potential.

Main Results:

  • Vascular stem and progenitor cells generate both vascular and nonvascular cells during development and disease.
  • Nonvascular stem and progenitor cells can contribute to vascular lineages.
  • The vasculature plays a critical role in establishing stem and progenitor cell niches.

Conclusions:

  • Understanding the reciprocal relationship between stem cells and vasculature is vital for disease etiology and treatment.
  • Further research into these interactions holds therapeutic promise.

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