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Updated: May 27, 2026

Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex
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Published on: August 2, 2021

How CD95 stimulates invasion.

Ernst J A Steller1, Inne H M Borel Rinkes, Onno Kranenburg

  • 1Department of Surgery, University Medical Centre, Utrecht, The Netherlands.

Cell Cycle (Georgetown, Tex.)
|November 9, 2011
PubMed
Summary
This summary is machine-generated.

CD95 receptor signaling activates non-apoptotic pathways, promoting cell migration and tissue invasion. This process involves extracellular matrix degradation and actin-driven cell protrusions, crucial in inflammation and tumor biology.

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Published on: April 24, 2015

Area of Science:

  • Cell biology
  • Molecular signaling
  • Cancer biology

Background:

  • CD95 (also known as Fas receptor) is primarily known for inducing programmed cell death (apoptosis).
  • However, CD95 also activates various non-apoptotic signaling pathways.
  • These pathways are implicated in critical biological processes like inflammation, neurobiology, and tumor progression.

Purpose of the Study:

  • To review the non-apoptotic signaling pathways initiated by CD95.
  • To elucidate the mechanisms by which CD95 promotes cell migration and tissue invasion.
  • To discuss the cooperative roles of these pathways in facilitating invasion.

Main Methods:

  • Literature review of studies on CD95 signaling.
  • Analysis of molecular mechanisms underlying CD95-mediated cell migration.
  • Examination of pathways involving extracellular matrix proteases, Rac, and cofilin.

Main Results:

  • CD95 signaling promotes migration and invasion in apoptosis-resistant cells.
  • Mechanisms include stimulating extracellular matrix (ECM)-degrading proteases.
  • CD95 also drives actin-driven cell protrusions via Rac and cofilin pathways.

Conclusions:

  • CD95 plays a significant role in cell migration and tissue invasion through non-apoptotic signaling.
  • Understanding these pathways is vital for addressing roles in inflammation, neurobiology, and cancer.
  • Cooperation between CD95-initiated pathways facilitates cell invasion processes.