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Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

Updated: May 27, 2026

Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
07:50

Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study

Published on: April 18, 2025

Oncologic emergencies: new decade, new perspectives.

Regan Demshar1, Rachel Vanek, Polly Mazanec

  • 1University Hospitals Case Medical Center/Seidman Cancer Center, Cleveland, OH 44106, USA. regan.demshar@uhhospitals.org

AACN Advanced Critical Care
|November 9, 2011
PubMed
Summary

Oncologic emergencies requiring intensive care have shifted from classic conditions to respiratory failure, sepsis, and hemodynamic instability. Modern management focuses on proactive interventions and critical care for these evolving patient needs.

Related Experiment Videos

Last Updated: May 27, 2026

Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
07:50

Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study

Published on: April 18, 2025

Area of Science:

  • Critical Care Medicine
  • Oncology
  • Emergency Medicine

Background:

  • The management landscape for oncologic emergencies has evolved significantly over the last decade.
  • Classic oncologic emergencies are now frequently managed outside the intensive care unit (ICU).

Purpose of the Study:

  • To outline the current evidence-based management of emergent conditions in cancer patients requiring ICU admission.
  • To summarize classic oncologic emergencies and highlight the critical care nurse's role.

Main Methods:

  • Review of current evidence-based management strategies for emergent oncologic conditions.
  • Discussion of classic oncologic emergencies and their contemporary management.
  • Integration of Ferrell's quality of life model for nursing care.

Main Results:

  • Emergent conditions necessitating ICU transfer now primarily include respiratory failure, cardiac emergencies, hemorrhagic events, coagulopathies, sepsis, and hemodynamic instability.
  • Proactive monitoring, early intervention, and aggressive management have shifted classic emergencies like superior vena cava syndrome and tumor lysis syndrome to less acute settings.
  • Critical care nurses play a vital role in addressing the complex needs of critically ill cancer patients and their families.

Conclusions:

  • The focus of oncologic emergencies in the ICU has shifted towards conditions like sepsis and respiratory failure.
  • Evidence-based critical care is essential for managing life-threatening complications in cancer patients.
  • Nursing care, guided by quality of life models, is integral to managing critically ill cancer patients and their families.