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[Delimiting the molecular envelope of a protein by deconvolution of the Patterson function for native proteins]
1Unité d'Immunologie Structurale, Institut Pasteur, Paris, Cedex, France.
Abstract:
A process, based on the superposition method, is described to delimit the molecular envelope of a protein by deconvolution of the Patterson function. The object is to obtain a preliminary set of phases from native structure-factor amplitudes with only native intensity data. The method has been tested with data from two immunoglobulin Fab fragments, Fab NEW and Fab R19.9. Several zones of resolution were explored.