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Related Experiment Videos

Biomaterials for implanted closed loop insulin delivery system: a review.

E Wilkins1, W Radford

  • 1University of New Mexico, Department of Chemical & Nuclear Engineering, Albuquerque 87131.

Biosensors & Bioelectronics
|January 1, 1990
PubMed
Summary

This study evaluates carbons, glass/ceramics, polymers, hydrogels, and collagen as biomaterials for artificial implants. It details their properties and biological responses for applications like artificial pancreas components.

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Area of Science:

  • Biomaterials science
  • Medical device engineering
  • Tissue engineering

Background:

  • Artificial implants require advanced biomaterials for safe and effective integration.
  • Understanding material properties and biological interactions is crucial for implant success.
  • Current research focuses on developing materials for complex applications like artificial organs.

Purpose of the Study:

  • To assess the suitability of five material classes (carbons, glass/ceramics, polymers, hydrogels, collagen) as biomaterials for artificial implants.
  • To analyze the physical, structural, blood, and tissue responses associated with these materials.
  • To emphasize materials relevant for specific applications, such as components of an artificial pancreas.

Main Methods:

  • Literature review and analysis of existing data on material properties.

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  • Evaluation of biocompatibility based on blood and tissue response studies.
  • Focus on materials applicable to implantable devices like catheter tips and glucose biosensors.

    • Main Results:

    • Detailed examination of the physical and structural characteristics of the five material groups.
    • Presentation of in vivo and in vitro data on blood compatibility and tissue integration.
    • Identification of promising materials for specific implantable device applications.

    Conclusions:

    • The five material groups show varied potential for artificial implant applications.
    • Material selection must consider specific application requirements and biological interactions.
    • Further research is needed to optimize biomaterials for advanced implantable systems, particularly for artificial pancreas development.