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Published on: June 18, 2020
Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI
Ruijun Xing1, Fan Zhang, Jin Xie
1Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA.
Nanoscale
|November 9, 2011
Summary
We developed a simple method to make hydrophobic manganese oxide nanoparticles (MONPs) water-soluble using polyaspartic acid (PASP). Smaller 10 nm PASP-MONPs showed better MRI enhancement in liver imaging compared to larger ones.
Area of Science:
- Nanotechnology
- Biomedical Imaging
- Materials Science
Background:
- Hydrophobic nanoparticles face challenges in aqueous biomedical applications.
- Manganese oxide nanoparticles (MONPs) show potential for MRI contrast agents.
- Surface modification is crucial for nanoparticle biocompatibility and dispersion.
Purpose of the Study:
- To develop a facile surface modification strategy for hydrophobic MONPs.
- To enable the transfer of MONPs into aqueous environments for biomedical use.
- To investigate the impact of nanoparticle size on MRI performance.
Main Methods:
- Surface modification of manganese oxide nanoparticles (MONPs) using polyaspartic acid (PASP).
- Characterization of PASP-MONPs in aqueous solution.
- In vivo MRI studies of normal liver using PASP-MONPs of varying sizes.
Main Results:
- Successful transfer of hydrophobic MONPs into water using PASP.
- PASP-MONPs demonstrated size-dependent MRI enhancement in liver.
- MONPs with a 10 nm core size exhibited superior MRI enhancement compared to larger particles.
Conclusions:
- Polyaspartic acid (PASP) provides an effective strategy for aqueous dispersion of manganese oxide nanoparticles (MONPs).
- Optimizing MONP size is critical for enhancing MRI contrast efficacy.
- This approach offers potential for developing advanced MRI contrast agents.
