In situ mechanical analysis of cardiomyocytes at nano scales
Yuansheng Liu1, Jiantao Feng, Liang Shi
1Emergency Department, Peking University People's Hospital, Beijing 100044, People's Republic of China.
Nanoscale
|November 9, 2011
Abstract:
Nanomechanical behaviors of single living cardiomyocytes are quantitatively observed using calculated torsions and deflections of an AFM cantilever. The lateral contractions are related to the calcium intensity within rather than the vertical beating power of the cardiomyocytes. Drug-induced nanomechanical changes of cardiomyocytes were further investigated by measuring lateral contractions in real time.
