Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ossification in nude mice. 1. Macroscopical study.

K Smetana1, M Holub

  • 1Department of Anatomy, Faculty of Medicine, Charles University, Prague, Czechoslovakia.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|August 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Reduction of the Cell Nuclear Size in the Cell Body Space During the Differentiation Might Be Cell Lineage Specific (A Retrospective Morphological Note).

Physiological research·2023
Same author

RNA Concentration and Content in the Nucleoli and Cytoplasmic Rim in Differentiating Lymphocytes of Patients Suffering from B Chronic Lymphocytic Leukaemia - a Cytochemical Note.

Folia biologica·2022
Same author

The Morphology of Cell Differentiation, Terminal Differentiation and Ageing Seems To Reflect the Same Process: a Short Note.

Folia biologica·2021
Same author

The cell body space occupied by the nucleus during the cell differentiation in human lymphocytic, granulocytic and erythroid cell lineages.

Physiological research·2021
Same author

Pediatric Inflammatory Multisystem Syndrome (PIMS) - Potential role for cytokines such Is IL-6.

Physiological research·2021
Same author

Genistein Induces Bcl-2 Expression in Human Dermal Microvascular Endothelial Cells: a Short Report.

Folia biologica·2021
Same journal

Immune Cell Composition and Prognosis in Node-Positive, Irradiated Breast Cancer Patients in the DBCG-IMN2 Study.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2026
Same journal

Urinary Secretory-IgA and IgG Responses and Inflammatory Markers in Patients With Pseudomonas aeruginosa Urinary Tract Infections.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2026
Same journal

Predictive Immunohistochemistry in Cholangiocarcinoma: Current Clinical Utility, Practical Limitations, and Emerging Directions.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2026
Same journal

Active Chlorine Antiseptics in Wound Care: Recent Advances and Perspectives for Military Medicine.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2026
Same journal

A Review on the Logistics, Financial, Ethical, and Regulatory Frameworks of Artificial Intelligence in Digital Pathology.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2026
Same journal

UE, CT, and ACR TI-RADS Grading in the Combined Diagnosis of Benign and Malignant Thyroid Nodules.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2026
See all related articles

Skeletal development in nu/nu mice shows similar ossification patterns to nu/+ mice early on. However, older nu/nu mice exhibit reduced bone density and growth plate thickness, suggesting postnatal factor influence.

Area of Science:

  • Developmental biology
  • Immunology
  • Skeletal biology

Background:

  • The nu/nu mouse model is characterized by athymia and lack of T-cells.
  • Understanding skeletal development in immunodeficient models is crucial for research.
  • Previous studies have not fully elucidated the long-term skeletal implications in nu/nu mice.

Purpose of the Study:

  • To compare the ossification patterns and skeletal development between nu/nu and nu/+ mice.
  • To investigate the influence of postnatal factors on skeletal maturation in nu/nu mice.

Main Methods:

  • Comparative study of skeletal ossification.
  • Analysis of cleared fetuses, newborns, and 1- and 6-week-old mice.
  • Radiographic assessment of skeletal density and tibial growth plate thickness.

Related Experiment Videos

Main Results:

  • Identical ossification patterns were observed in nu/nu and nu/+ mice during embryonic and early postnatal stages.
  • By 6 weeks of age, nu/nu mice displayed significantly lower skeletal X-ray density compared to nu/+ littermates.
  • A reduced thickness of the proximal tibial growth plate was noted in 6-week-old nu/nu mice.

Conclusions:

  • While early skeletal development is comparable, postnatal factors impact skeletal maturation in nu/nu mice.
  • The observed differences suggest that the absence of T-cells or other genetic factors in nu/nu mice influences bone development postnatally.
  • Further research is warranted to identify specific postnatal factors affecting skeletal integrity in nu/nu mice.