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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Related Experiment Video

Updated: May 27, 2026

Orthotopic Left Lung Transplantation in Rats
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Published on: July 3, 2025

Challenges in lung transplantation.

Thorsten Krueger1, Carine Berutto, John-David Aubert

  • 1Service de Chirurgie Thoracique et Vasculaire, CHUV, Lausanne, Switzerland.

Swiss Medical Weekly
|November 9, 2011
PubMed
Summary
This summary is machine-generated.

Lung transplantation faces challenges with organ availability and long-term complications like bronchiolitis obliterans. Innovative strategies, including using marginal donors and ex vivo lung assessment, show promise for improving outcomes.

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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Area of Science:

  • Thoracic Surgery
  • Transplantation Immunology
  • Pulmonary Medicine

Background:

  • Lung transplantation is a vital treatment for end-stage lung diseases in eligible patients.
  • Organ allocation for lung transplants is complex, influenced by policy, geography, and logistics.
  • Limited organ availability necessitates exploring strategies to expand the donor pool.

Purpose of the Study:

  • To review current challenges and emerging strategies in lung transplantation.
  • To highlight the potential of marginal donors and ex vivo lung assessment.
  • To discuss the persistent issue of chronic lung allograft dysfunction.

Main Methods:

  • Review of existing lung transplant allocation policies and their limitations.
  • Exploration of ex vivo assessment and restoration techniques for explanted lungs.
  • Analysis of long-term outcomes and complications, particularly bronchiolitis obliterans.

Main Results:

  • No single optimal lung transplant allocation system exists due to practical constraints.
  • Ex vivo assessment and restoration of lungs from marginal donors is a developing clinical practice.
  • Chronic lung allograft dysfunction, specifically bronchiolitis obliterans, remains a significant barrier to long-term survival.

Conclusions:

  • Addressing organ scarcity through marginal donors and ex vivo techniques is crucial.
  • Developing effective preventive strategies for bronchiolitis obliterans is paramount.
  • Further prospective studies are needed to validate new approaches in lung transplantation.