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Updated: May 27, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Current role of interventions in metastatic kidney tumors: single center experience
Gianpaolo Carrafiello1, Gianlorenzo Dionigi, Luigi Boni
1Radiology Department, University of Insubria, Viale Borri, 57, Varese, Italy. gcarraf@gmail.com
Abstract:
This study on the treatment of kidney tumor metastases aims to expose our experience in different interventional therapies for renal cell carcinomas metastasis in different organs, broaching their complications and comparing our results with the literature. In the last 5 years, after informed consent, 22 patients with metastatic kidney tumors were enrolled in this retrospective observational study. According to lesion sites, different interventional procedures may be performed: RFA for pancreas, lung, adrenal gland and liver lesions; TAE and RFA for bone lesions and IVC filter positioning for thrombosis of renal vein. There were mainly satisfactory results: complete necrosis of pancreas, lung and adrenal gland metastasis with a technical success rate of 100%; after TAE and RFA of bone lesions, an acceptable blood loss was registered during surgical intervention; no recurrences after liver metastasis ablation were observed in a period of 3 months; positioning of IVC filter was technically correct in 100% of patients; few complications, such as diffuse abdominal pain for pancreas, pneumothorax in the lung RCC metastasis and a post-RFA syndrome for the adrenal. There was a nodular recurrence along the ablation margin in one liver RCC metastasis. Inclusion criteria were relatively strict and only 22 patients were included in this study. The follow-up has been relatively short to date, so we are not certain of the long-term results, though these are comparable to those found in literature. It is possible to conclude that Interventional radiology plays an important role in RCC metastasis treatment, if we have few complications and improved outcomes.
Insights
Interventional radiology effectively treats kidney tumor metastases using procedures like RFA and TAE. This approach shows high success rates with manageable complications, offering improved outcomes for patients with metastatic renal cell carcinoma.
Area of Science:
- Interventional Radiology
- Oncology
- Nephrology
Background:
- Renal cell carcinoma (RCC) frequently metastasizes to various organs.
- Effective treatment of metastatic RCC remains a clinical challenge.
- Interventional radiology offers minimally invasive therapeutic options.
Purpose of the Study:
- To evaluate the experience and outcomes of interventional therapies for kidney tumor metastases.
- To analyze complications and compare results with existing literature.
- To assess the role of interventional radiology in managing metastatic renal cell carcinoma.
Main Methods:
- Retrospective observational study of 22 patients with metastatic kidney tumors over 5 years.
- Procedures included Radiofrequency Ablation (RFA) for pancreatic, lung, adrenal, and liver lesions.
- Transarterial Embolization (TAE) and RFA for bone lesions, and IVC filter placement for renal vein thrombosis were utilized.
Main Results:
- 100% technical success for RFA in pancreas, lung, and adrenal gland metastases, achieving complete necrosis.
- Acceptable blood loss during TAE and RFA for bone lesions.
- No recurrence observed in liver metastasis after 3 months; IVC filter placement was 100% successful.
- Minor complications included abdominal pain, pneumothorax, and post-RFA syndrome.
Conclusions:
- Interventional radiology demonstrates significant efficacy in treating renal cell carcinoma metastases.
- The procedures offer a favorable safety profile with few complications and improved patient outcomes.
- Interventional radiology is a valuable tool in the multidisciplinary management of metastatic kidney tumors.
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