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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
Published on: November 15, 2017
Trends in biomedical engineering: focus on Genomics and Proteomics
Linda Pattini1, Riccardo Bertacco, Gabriele Candiani
1Department of Bioengineering, Politecnico di Milano, Milano, Italy. pattini@biomed.polimi.it
Journal of Applied Biomaterials & Biomechanics : JABB
|November 9, 2011
Summary
Genomics and proteomics, the study of genes and proteins, are crucial for understanding cellular functions. These fields, supported by computational analysis, advance molecular medicine for better diagnosis and therapies.
Area of Science:
- Molecular Biology
- Genomics
- Proteomics
- Bioinformatics
Background:
- Genomics deciphers the cell's blueprint, revealing physiological mechanisms.
- Proteomics studies the functional protein molecules, adding complexity from gene to protein.
- Technological advancements enable gene and protein behavior analysis.
Purpose of the Study:
- To highlight the complementary roles of genomics and proteomics.
- To emphasize the necessity of computational approaches in molecular biology.
- To establish the framework for modern molecular medicine.
Main Methods:
- Genomic sequencing and analysis.
- Proteomic profiling and characterization.
- Application of mathematics, statistics, and informatics for data management.
Main Results:
- Integrated genomic and proteomic data provide a comprehensive view of cellular processes.
- Computational tools are essential for managing and interpreting large biological datasets.
- Understanding subcellular mechanisms under normal and disease states is achievable.
Conclusions:
- Genomics and proteomics are integral to advancing molecular medicine.
- Knowledge gained can improve diagnostic accuracy and therapeutic strategies.
- These fields drive innovation in drug development and personalized medicine.
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