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Updated: May 27, 2026

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure
Published on: January 18, 2021
Virtual reality exposure therapy in anxiety disorders: a quantitative meta-analysis
David Opriş1, Sebastian Pintea, Azucena García-Palacios
1Department of Clinical Psychology and Psychotherapy, Babeş-Bolyai University, Cluj-Napoca, Romania. david.opris@ubbcluj.ro
Virtual reality exposure therapy (VRET) is as effective as traditional treatments for anxiety disorders. This therapy shows lasting results and a dose-response relationship, offering a viable alternative for patients.
Area of Science:
- Psychiatry
- Psychology
- Behavioral Science
Background:
- Anxiety disorders represent a significant global health burden.
- Virtual reality exposure therapy (VRET) has emerged as a novel therapeutic approach.
- Evidence comparing VRET with established treatments is crucial.
Purpose of the Study:
- To conduct a meta-analysis comparing the efficacy of VRET within behavioral and cognitive-behavioral frameworks against classical evidence-based treatments for anxiety disorders.
- To evaluate the real-life impact and long-term stability of VRET outcomes.
Main Methods:
- A comprehensive literature search identified 23 studies with 608 participants.
- Meta-analysis was employed to synthesize data from included studies.
- Efficacy, real-life impact, and dropout rates were primary outcome measures.
Main Results:
- VRET demonstrated superior outcomes compared to waitlist controls for anxiety disorders.
- VRET showed comparable efficacy to traditional evidence-based treatments.
- VRET exhibited similar long-term stability and real-life impact as conventional therapies.
- A dose-response relationship was observed for VRET, and dropout rates were similar to in vivo exposure.
Conclusions:
- VRET is an effective treatment for anxiety disorders, comparable to established interventions.
- VRET offers durable and impactful therapeutic results.
- The findings support VRET as a valuable tool in the treatment of anxiety disorders.
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