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[Chemical constituents of Carya cathayensis and their antitumor bioactivity]

De-lin Wu¹, Shi-yun Chen, Jing-song Liu

¹College of Pharmaceutical Sciences of Anhui University of Traditional Chinese Medicine, Hefei 230031, China. dlwu7375@sina.com

Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials

|November 10, 2011

Abstract

Objective:

To investigate the chemical constituents of Carya cathayensis and their antitumor bioactivity.

Methods:

The compounds were isolated by Sephadex LH-20 and silica gel column chromatography. Their structures were identified by physicochemical properties and spectroscopic analysis. Then their cytotoxic activity was studied.

Results:

Five compounds were elucidated as chrysophanol (1), physcion (2), beta-sitosterol (3), pinostrobin(4), 4,8-dihydroxy-1-tetralone (5).

Conclusion:

Compounds 2 and 5 are isolated from Carya cathayensis for the first time. In the MTT antitumor experiments, the compounds 1,4 and 5 have the cytotoxic activity to KB cell.

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