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Published on: August 12, 2016
Altered phosphate metabolism in HIV-1-infected patients with metabolic syndrome
Pierfrancesco Grima1, Marcello Guido, Roberto Chiavaroli
1Division of Infectious Diseases, HIV Centre, S. Caterina Novella Hospital, via Roma, Galatina, Italy. pierfrancescogrima@yahoo.it
Background:
Metabolic syndrome (MS) represents a cluster of cardiovascular risk factors that has become a serious problem for HIV-1-infected patients. It has been proposed that disturbance of phosphate metabolism may represent a key feature of MS. Thus, we undertook the present study to investigate the relationship between phosphate levels and the presence of the characteristics of MS.
Methods:
One hundred and twenty-one HIV-1-infected patients were consecutively enrolled in a prospective, cross-sectional, single-centre study. Kidney tubular function was examined using tubular resorption of phosphate and normalized renal threshold phosphate concentration.
Results:
Univariate analysis showed that serum phosphate levels correlated negatively with systolic and diastolic blood pressure, glucose values, waist circumference, insulin, and triglycerides. Moreover, there was a positive relationship between phosphate and high-density lipoprotein (HDL) cholesterol. Multivariate analysis showed that insulin levels were correlated with serum phosphate concentration (r = - 0.24, p = 0.01).
Conclusions:
Our data show that HIV-1-infected patients with MS have lower phosphate levels.
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