Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Titrimetric Methods: Types and Commonly Used Strategies01:08

Titrimetric Methods: Types and Commonly Used Strategies

In chemistry, titrimetric methods are broadly classified into three types: volumetric, gravimetric, and coulometric. Volumetric titrations involve measuring the volume of a titrant of known concentration that is required to react completely with an analyte. In gravimetric titrations, the standard solution reacts with the analyte to form an insoluble precipitate, which is filtered, dried, and weighed. In coulometric titrations, current is applied to an electrochemical reaction until the reaction...
EDTA: Indirect and Alkalimetric Titration01:23

EDTA: Indirect and Alkalimetric Titration

Unlike direct titration, back-titration, and displacement titration, indirect titration is an EDTA titration method for quantifying anions. In the indirect titration method, anions are precipitated as their insoluble salts with excess metal ions. The filtrate containing the excess metal ions is directly titrated with standard EDTA until the endpoint is achieved. Another approach involves extracting the metal ion and back-titrating with standard EDTA to obtain the endpoint. In this way, the...
EDTA: Direct, Back-, and Displacement Titration01:30

EDTA: Direct, Back-, and Displacement Titration

The EDTA titration types for metal ion analysis include direct titration, back-titration, and replacement titration.
Direct titration involves buffering the metal ion solution to the desired pH and directly titrating with standard EDTA until the endpoint. The optimum pH ensures a large conditional formation constant of metal−EDTA and visibility of the free indicator color in the solution. In addition, auxiliary complexing reagents are used to prevent the precipitation of metal hydroxides and...
Controlled-Current Coulometry: Coulometric Titration01:18

Controlled-Current Coulometry: Coulometric Titration

Coulometric titrations are a form of titrimetric analysis where the reagent is generated electrically, and its amount is evaluated based on current and generating time. The electron serves as the standard reagent. The procedure is similar to conventional titrations, such as endpoint detection.
The fundamental requirements for coulometric titrations are (1) 100% efficiency in the reagent-generating electrode reaction and (2) a stoichiometric and preferably rapid reaction between the generated...
Classification of Titrimetric Analysis Based on Reaction Types01:01

Classification of Titrimetric Analysis Based on Reaction Types

Titrimetric analysis in solution chemistry involves measuring the volume of solutions and is often called volumetric analysis. The standard solution of known concentration in the burette is called the titrant, whereas the solution of unknown concentration in the flask is called the analyte, or titrand. Titrimetric analyses can be classified into four types based on the reactions between the titrant and analyte.
Titrations between an acid and a base lead to neutralization reactions that form...
Complexometric Titration: Overview00:39

Complexometric Titration: Overview

Complexometric titration involves the formation of a complex by reacting a metal ion with one or more ligands. A visual indicator often detects the end point of a complexometric titration. It is added to the metal solution before the titration, forming a stable metal–indicator complex and imparting color to the solution. As the titration approaches the equivalence point, the excess of the added ligand displaces the indicator from the metal–indicator complex, releasing the free indicator. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seawater Calibration Systems for Oceanographic Implementation of Iron(III) Ion-Selective Electrodes.

ACS sensors·2026
Same author

Developmental Change in Structure Learning Reflects a Shift From Recency-Based to Relational Prediction.

Developmental science·2026
Same author

Configurable Modular EEG Classification Framework with Multiscale Features and Ensemble Learning: A Reproducible Evaluation for Schizophrenia Detection.

Bioengineering (Basel, Switzerland)·2026
Same author

"Smart" harm reduction vending machines to improve public health: Evaluating the utilization.

Journal of substance use and addiction treatment·2026
Same author

Interventions Benefitting Young Autistic Children.

Education & treatment of children·2026
Same author

Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence.

Aging·2025
Same journal

The ACS at 150: The History of Analytical Chemistry Publications and a Century of Progress.

Analytical chemistry·2026
Same journal

Machine Learning-Enabled Image Analysis of Complex Chemical Mixtures: Synthetic Urine Droplets as a Test System.

Analytical chemistry·2026
Same journal

H<sub>2</sub>O<sub>2</sub>/Viscosity Tandem-Locked Fluorescent Probes Based on an In Situ Fluorophore Synthesis Strategy for Colitis Imaging and Diagnosis.

Analytical chemistry·2026
Same journal

TopoStitcher: A Geometric-Topological Structure-Guided Stitching Framework for Single-Molecule Localization Microscopy.

Analytical chemistry·2026
Same journal

Noninvasive SERS Immunosensing of Tyrosinase for Melanoma Monitoring via Microneedle Sampling Integrated with Satellite-Structured Bifunctional Nanozymes.

Analytical chemistry·2026
Same journal

Label-Free Electrochemical CRISPR Platform Gated by Allosteric Transcription Factors for Ultrasensitive Small-Molecule Detection.

Analytical chemistry·2026
See all related articles

Related Experiment Video

Updated: May 27, 2026

Isothermal Titration Calorimetry for Measuring Macromolecule-Ligand Affinity
08:45

Isothermal Titration Calorimetry for Measuring Macromolecule-Ligand Affinity

Published on: September 7, 2011

Universal tracer monitored titrations.

Michael D DeGrandpre, Todd R Martz, Robert D Hart

    Analytical Chemistry
    |November 10, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Titrations can be simplified using tracers, eliminating the need for volume or mass measurements. This innovation enables easier chemical analysis in labs and remote field applications.

    More Related Videos

    Quantifying the Binding Interactions Between Cu(II) and Peptide Residues in the Presence and Absence of Chromophores
    11:38

    Quantifying the Binding Interactions Between Cu(II) and Peptide Residues in the Presence and Absence of Chromophores

    Published on: April 5, 2022

    Measuring Enzymatic Stability by Isothermal Titration Calorimetry
    08:37

    Measuring Enzymatic Stability by Isothermal Titration Calorimetry

    Published on: March 26, 2019

    Related Experiment Videos

    Last Updated: May 27, 2026

    Isothermal Titration Calorimetry for Measuring Macromolecule-Ligand Affinity
    08:45

    Isothermal Titration Calorimetry for Measuring Macromolecule-Ligand Affinity

    Published on: September 7, 2011

    Quantifying the Binding Interactions Between Cu(II) and Peptide Residues in the Presence and Absence of Chromophores
    11:38

    Quantifying the Binding Interactions Between Cu(II) and Peptide Residues in the Presence and Absence of Chromophores

    Published on: April 5, 2022

    Measuring Enzymatic Stability by Isothermal Titration Calorimetry
    08:37

    Measuring Enzymatic Stability by Isothermal Titration Calorimetry

    Published on: March 26, 2019

    Area of Science:

    • Analytical Chemistry
    • Chemical Sensing

    Background:

    • Traditional titrations rely on precise volumetric or gravimetric measurements.
    • Autonomous sensing demands simplified analytical methods for remote applications.

    Discussion:

    • A novel titrimetric method uses tracers to eliminate volumetric/gravimetric measurements.
    • This tracer-based approach was initially developed for seawater alkalinity analysis.
    • The method's versatility is demonstrated across diverse titration types and tracers.

    Key Insights:

    • Tracers in titrants negate the need for measuring sample or titrant volume/mass.
    • This tracer method significantly simplifies titration procedures.
    • The approach is adaptable to a wide range of chemical titrations.

    Outlook:

    • Enables simplified laboratory and field-based chemical analysis.
    • Facilitates the development of autonomous and remote sensing analytical devices.
    • Potential for broader application in chemical analysis beyond the current scope.