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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
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Serum mercury level and multiple sclerosis.

Ahmad Movahedian Attar1, Azam Kharkhaneh, Masoud Etemadifar

  • 1Department of Clinical Biochemistry, Isfahan Pharmaceutical Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.

Biological Trace Element Research
|November 10, 2011
PubMed
Summary

High serum mercury levels were found in multiple sclerosis patients compared to healthy individuals. This suggests mercury exposure may contribute to multiple sclerosis development in susceptible populations.

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Area of Science:

  • Environmental Health
  • Neurology
  • Toxicology

Background:

  • Heavy metal exposure is linked to increased multiple sclerosis (MS) incidence.
  • Understanding environmental factors contributing to MS is crucial for prevention and treatment.

Purpose of the Study:

  • To investigate the association between serum mercury levels and the development of multiple sclerosis (MS).
  • To compare mercury concentrations in the serum of MS patients and healthy controls in Isfahan, Iran.

Main Methods:

  • A case-control study involving 74 MS patients and 74 age- and sex-matched healthy controls.
  • Serum mercury levels were quantified using [specific method not detailed in abstract].
  • Statistical analysis was performed to compare mercury levels and calculate odds ratios.

Main Results:

  • Serum mercury levels were significantly higher in MS patients (9.6 ± 10.17) compared to controls (5.7 ± 8.6).
  • MS patients exhibited an odds ratio of 2.39 (CI, 1.96-2.94) for elevated serum mercury compared to healthy individuals.
  • A statistically significant difference was observed (P=0.037 for patient vs. control levels, P=0.00 for overall association).

Conclusions:

  • Elevated serum mercury levels are associated with multiple sclerosis.
  • High mercury levels may play a role in the development of MS in genetically susceptible individuals.
  • Further research with larger sample sizes is warranted to confirm these findings.