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Related Experiment Video

Updated: May 27, 2026

A Rat Model of Compound Acne

A Rat Model of Compound Acne

Published on: November 1, 2024

Disabling acne fulminans.

Tiago Pina Zanelato¹, Gabriela Maria Abreu Gontijo, Célia Antônia Xavier de Moares Alves

¹serviço de Dermatologia, Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brasil. tizanelato@hotmail.com

Anais Brasileiros De Dermatologia

|November 10, 2011

Summary

Acne fulminans, a rare condition, can manifest in male adolescents with severe acne. This case highlights its development alongside sacroiliitis after isotretinoin therapy.

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Area of Science:

Dermatology
Rheumatology
Adolescent Medicine

Background:

Acne fulminans is a rare, severe variant of acne vulgaris.
It primarily affects male adolescents and can be triggered by isotretinoin, testosterone, or immune responses.
Characteristic symptoms include fever, hepatomegaly, polyarthralgia, and elevated inflammatory markers.

Observation:

A male adolescent with grade III acne vulgaris was treated with isotretinoin.
Following treatment initiation, the patient developed acne fulminans.
The patient also presented with bilateral sacroiliitis, leading to inability to ambulate.

Findings:

The case demonstrates a link between isotretinoin therapy and the onset of acne fulminans.
Bone scans can reveal osteolytic lesions in patients with acne fulminans.
Laboratory findings included leukocytosis, thrombocytosis, elevated inflammatory markers, and transaminases.

Implications:

This case underscores the importance of recognizing acne fulminans and its potential musculoskeletal complications, such as sacroiliitis.
Early diagnosis and appropriate management, including corticosteroids and potentially antibiotics, are crucial.
Further research may elucidate the precise mechanisms linking isotretinoin and immune-mediated inflammatory conditions like acne fulminans and sacroiliitis.