Diffuse plane xanthomatosis associated with monoclonal gammopathy

Area of Science:

• Dermatology
• Hematology
• Oncology

Background:

• Diffuse plane normolipemic xanthomatosis (DPNX) is a rare, non-inherited disorder.
• DPNX is frequently associated with systemic conditions, particularly hematological malignancies such as multiple myeloma and lymphoproliferative disorders.

Observation:

• DPNX can manifest years before the diagnosis of associated systemic diseases.
• This case highlights a DPNX presentation linked with monoclonal gammopathy.
• Dermatological manifestations of DPNX can be the initial clinical sign of significant hematological conditions.

Findings:

• The study presents a case of DPNX associated with monoclonal gammopathy.
• It underscores the potential of DPNX as an early indicator of underlying hematological diseases.

Implications:

• Physicians should be aware of DPNX as a potential herald of serious hematological disorders.
• Regular follow-up and laboratory testing are crucial for patients with DPNX, even in the absence of apparent underlying disease.
• Early recognition of DPNX can lead to timely diagnosis and management of associated systemic conditions.