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Related Experiment Videos

Risk factors in internal urinary system malformations.

C Stoll1, Y Alembik, M P Roth

  • 1Institut de Puériculture, Hôpital Civil, Strasbourg, France.

Pediatric Nephrology (Berlin, Germany)
|July 1, 1990
PubMed
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Internal urinary system (IUS) anomalies affect 3.51 per 1,000 births, often linked to genetic factors and other malformations. Prenatal ultrasound screening effectively detects these fetal conditions.

Area of Science:

  • Pediatric Urology
  • Medical Genetics
  • Prenatal Diagnosis

Background:

  • Internal urinary system (IUS) anomalies are significant congenital conditions.
  • Understanding associated risk factors and co-occurring malformations is crucial for diagnosis and management.
  • Prenatal diagnosis plays a key role in identifying these anomalies early.

Purpose of the Study:

  • To investigate risk factors associated with internal urinary system anomalies in a large cohort of newborns.
  • To determine the incidence of IUS anomalies and their co-occurrence with other malformations.
  • To evaluate the effectiveness of prenatal ultrasound screening for IUS anomalies.

Main Methods:

  • A case-control study involving 370 children with IUS anomalies and 105,374 births.

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  • Assessment of various risk factors including parental demographics, genetic factors, and environmental influences.
  • Analysis of co-occurring non-urinary malformations, chromosomal abnormalities, and pregnancy complications like oligo-amnios.

    • Main Results:

    • The incidence of IUS malformations was 3.51 per 1,000 births, with 54.4% diagnosed prenatally.
    • Children with IUS anomalies had lower birth weight, length, and head circumference compared to controls.
    • Increased consanguinity and a higher incidence of non-urinary malformations were observed in affected families.

    Conclusions:

    • Prenatal ultrasound screening demonstrates high efficacy in detecting fetal urinary tract malformations.
    • IUS anomalies are associated with specific genetic and environmental risk factors, as well as a high rate of extra-urinary malformations.
    • Early detection and comprehensive assessment are vital for managing infants with IUS anomalies.