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Polypeptide growth factors and the kidney: a developmental perspective
1Division of Pediatric Nephrology, Children's Hospital and Medical Center, Seattle, Washington.
Abstract:
A variety of polypeptides with stimulatory or inhibitory effects on cell proliferation have been identified. In addition to stimulating or inhibiting the proliferation of cells and maintaining their viability, polypeptide growth factors play significant roles in embryogenesis and differentiation. The current review focuses on five specific polypeptide growth factor families (epidermal growth factor, insulin-like growth factors, transforming growth factors, platelet-derived growth factor, and fibroblast growth factors) and discusses their possible relationship to normal renal physiology, abnormal renal pathophysiology, and renal organogenesis. On the basis of current data, it is clear that polypeptide growth factors are multifunctional agents with important effects on renal function and renal organogenesis.
Insights
Polypeptide growth factors influence cell proliferation, viability, and differentiation. This review examines their roles in kidney function, disease, and development, highlighting their multifunctional nature in renal organogenesis.
Area of Science:
- Biochemistry and Molecular Biology
- Developmental Biology
- Nephrology
Background:
- Polypeptide growth factors regulate cell proliferation, viability, embryogenesis, and differentiation.
- These factors are crucial for normal physiological processes and development.
Purpose of the Study:
- To review the roles of five key polypeptide growth factor families in renal physiology and pathophysiology.
- To explore their involvement in renal organogenesis.
Main Methods:
- Literature review of scientific data on polypeptide growth factors.
- Focus on epidermal growth factor, insulin-like growth factors, transforming growth factors, platelet-derived growth factor, and fibroblast growth factors.
Main Results:
- Polypeptide growth factors exhibit diverse effects on renal cells.
- These factors are implicated in both normal kidney function and disease states.
- Evidence suggests significant roles in kidney development and organogenesis.
Conclusions:
- Polypeptide growth factors are multifunctional agents impacting renal function.
- They play critical roles in renal organogenesis and pathophysiology.