Related Experiment Videos
Relation of leptin, adiponectin and insulin resistance to bone mineral density in type 2 diabetic postmenopausal
Banu Kale Koroglu1, Fatma Kiris, Ismail Hakki Ersoy
1Department of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Suleyman Demirel University, Turkey.
Background:
Our aim is to identify the relation of leptin, adiponectin and insulin resistance to bone mineral density (BMD) in type 2 diabetic postmenopausal women and compare it with that experienced by nondiabetics.
Material And Methods:
Seventy six postmenopausal female patients were included in the study. Postmenopausal type 2 diabetic (n = 19) and nondiabetic patients (n = 19) with spine and/or hip BMD T score lower than -2 were included in the study, and postmenopausal type 2 diabetic (n = 20) and nondiabetic women (n = 18) with normal BMD (T score > -1) were selected as control groups. Those receiving therapy for osteoporosis, over the age of 65, those who had a disease and were taking a medication that could affect bone metabolism were excluded. Biochemical tests, as well as leptin, adiponectin and insulin levels, were measured and insulin resistance was calculated using the HOMA test.
Results:
There was no correlation between low BMD and leptin, adiponectin and insulin resistance. There was only a negative correlation between leptin and femur Ward's triangle BMD.
Conclusion:
Further large-scale studies must to be performed in order to analyse the effects of leptin, adiponectin and insulin resistance on bone metabolism in type 2 diabetic patients.
Related Concept Videos
Type II Diabetes II: Pathophysiology
Type II Diabetes I: Introduction
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Diabetes Mellitus: Type 2 and Gestational
Obesity
Type I Diabetes III: Clinical Manifestations