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Updated: May 27, 2026

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
Published on: May 15, 2021
Mechanisms of Cisplatin nephrotoxicity
Ronald P Miller1, Raghu K Tadagavadi, Ganesan Ramesh
1Division of Nephrology, The Pennsylvania State University College of Medicine, Hershey, PA, USA. RMiller8@hmc.psu.edu
Abstract:
Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatin-induced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.
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