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Related Experiment Video

Updated: May 27, 2026

In vitro Cell Migration and Invasion Assays

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

Snake venom disintegrins and cell migration.

Heloisa S Selistre-de-Araujo¹, Carmen L S Pontes, Cyntia F Montenegro

¹Departamento de Ciências Fisiológicas, Universidade Federal de São Carlos, São Carlos, SP, 13565-905, Brazil. hsaraujo@ufscar.br

|November 10, 2011

Summary

Disintegrins, small proteins that bind integrins, are expected to inhibit cell migration by blocking cell adhesion. This review explores their effects on cell movement and potential therapeutic applications in inflammation and cancer metastasis.

Keywords:

ADAM cell migration disintegrin snake venom αvβ3 integrin

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In vitro Cell Migration and Invasion Assays

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Published on: December 4, 2012

Area of Science:

Cell Biology
Biochemistry
Pharmacology

Background:

Cell migration is crucial for multicellular organism defense against pathogens.
Integrins are key surface receptors mediating cell-extracellular matrix interactions and directing cell movement.
Integrin clustering at focal adhesions drives actin polymerization, establishing cell polarity.

Purpose of the Study:

To review the effects of disintegrins and disintegrin-like proteins on cell migration.
To explore their potential as pharmacological agents for anti-inflammatory therapy.
To assess their utility in inhibiting metastatic invasion.

Main Methods:

Literature review of studies on disintegrins and cell migration.
Analysis of integrin-binding proteins and their mechanism of action.
Evaluation of therapeutic potential based on existing research.

Main Results:

Disintegrins inhibit integrin-mediated cell adhesion, a critical step in cell migration.
These proteins are expected to impede cell movement due to their inhibitory effects on integrins.
Evidence suggests potential applications in managing inflammatory diseases and preventing cancer spread.

Conclusions:

Disintegrins represent a class of molecules with significant impact on cell migration processes.
Their ability to inhibit integrin function offers therapeutic promise for inflammatory conditions.
Disintegrins may serve as novel agents to combat tumor metastasis.