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Pasteurella multocida toxin activates various heterotrimeric G proteins by deamidation

Joachim H C Orth1, Klaus Aktories

  • 1Institute for Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, 79104 Freiburg, Germany. Joachim.Orth@pharmakol.uni-freiburg.de

Toxins
|November 10, 2011
PubMed
Summary

Pasteurella multocida toxin (PMT) activates G proteins by preventing GTP hydrolysis, leading to altered cellular signaling. This study details PMT's molecular mechanism and its impact on cell pathways.

Keywords:
G proteinGTPaseGα12/13GαiGαqdeamidationα-subunit

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