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Elastic fibre damage induced by low-dose D-penicillamine
K L Dalziel1, S M Burge, P A Frith
1Department of Dermatology, Slade Hospital, Oxford, U.K.
The British Journal of Dermatology
|September 1, 1990
Abstract:
We have studied 23 patients receiving penicillamine for the treatment of rheumatoid arthritis to determine the prevalence of penicillamine-induced elastosis. One female patient had pseudoxanthoma elasticum-like skin changes and bramble-bush elastosis without calcification in the involved skin. Penicillamine elastosis was present in the joint capsule in 62% of eight patients or 64% of II joints examined and was detected in joint capsules after as little as I year of treatment.