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Serum lipoproteins during bone marrow hyperplasia after phenylhydrazine administration in rats
1Istituto di Farmacologia e Patologia Biochimica, Università di Cagliari, Italy.
International Journal of Experimental Pathology
|October 1, 1990
Abstract:
In the present study, lipoprotein metabolism was investigated during compensatory hyperplasia of bone marrow after haemolysis induced by phenylhydrazine (20 mg/kg b.w.) administration in rats. The rats were sacrificed at different time intervals (0, 1, 2 and 5 days) after phenylhydrazine treatment. Analysis of the different fractions of lipoproteins has shown that during bone marrow hyperplasia there is an alteration of lipoprotein profiles, mainly due to a decrease of HDL2 and HDL3 subfractions.