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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Asymptomatic cardiovascular manifestations in diabetes mellitus: left ventricular diastolic dysfunction and silent

Jelena P Seferović-Mitrović1, Nebojsa M Lalić, Bosiljka Vujisić-Tesić

  • 1Department of Endocrinology, Diabetes, and Metabolic Disorders, Clinical Centre of Serbia, Belgrade, Serbia. jpseferovic@yahoo.com

Srpski Arhiv Za Celokupno Lekarstvo
|November 11, 2011
PubMed

Insights

This study found that 17.3% of type 2 diabetes patients have asymptomatic cardiovascular complications like left ventricular diastolic dysfunction (LVDD) and silent myocardial ischemia (SMI). Early detection is key for managing diabetes-related heart issues.

Area of Science:

  • Cardiology
  • Diabetology
  • Internal Medicine

Background:

  • Cardiovascular complications in diabetes can be asymptomatic.
  • Left ventricular diastolic dysfunction (LVDD) is an early metabolic lesion in diabetic patients, detectable by tissue Doppler echocardiography.
  • Silent myocardial ischemia (SMI) is a common ischemic heart disease manifestation in diabetes.

Purpose of the Study:

  • To determine the prevalence of LVDD and SMI in type 2 diabetes patients.
  • To compare demographic, clinical, and metabolic data between patients with and without LVDD and SMI.

Main Methods:

  • Investigated 104 type 2 diabetic patients with varying blood pressure levels.
  • Conducted laboratory assessments, transthoracic echocardiography with tissue Doppler, and exercise stress echocardiography.

Main Results:

  • LVDD was diagnosed in 11.5% and SMI in 5.8% of patients.
  • Patients with LVDD used metformin less frequently compared to other groups.
  • Higher HDL cholesterol and apolipoprotein A1 levels were observed in patients with LVDD.

Conclusions:

  • The study identified asymptomatic cardiovascular complications in 17.3% of type 2 diabetes patients.
  • Highlights the importance of screening for cardiac abnormalities in diabetic individuals.
Abstract

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