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Updated: May 27, 2026
04:42
Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Late-onset bipolar illness: the geriatric bipolar type VI
Jean-Michel Azorin1, Arthur Kaladjian, Marc Adida
1Pôle Universitaire de Psychiatrie-Solaris, Hôpital Sainte-Marguerite, Cedex, France. jazorin@ap-hm.fr
CNS Neuroscience & Therapeutics
|November 11, 2011
Summary
Late-onset bipolar illness (LOBI) is complex and understudied. Research highlights LOBI
Area of Science:
- Geriatric Psychiatry
- Neuroscience
- Psychiatry
Background:
- Late-onset bipolar illness (LOBI) remains understudied despite advances in bipolar disorder research and geriatric psychiatry.
- The complexity of LOBI necessitates a comprehensive review of existing literature to update current understanding.
Purpose of the Study:
- To systematically review and synthesize current data on late-onset bipolar illness (LOBI).
- To identify and analyze key issues surrounding LOBI, including its epidemiology, clinical features, and treatment.
Main Methods:
- A systematic literature review was conducted.
- The review focused on identifying and analyzing five main issues related to LOBI.
Main Results:
- Key issues identified include LOBI as a secondary disorder, an expression of lower vulnerability, a pseudodementia subtype, a dementia risk factor, and bipolar type VI.
- Evidence levels varied across these identified issues.
- The concept of bipolar type VI, while potentially encompassing diverse presentations, offers pragmatic clinical value for diagnosis and treatment orientation.
Conclusions:
- Further research is crucial to investigate LOBI as a potential risk factor for developing dementia.
- More studies are needed to differentiate the effects of age at onset from the effects of aging itself on LOBI.
- The concept of bipolar type VI warrants further consideration for its clinical utility in managing LOBI.
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