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Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Chemical modifications of algal mannans and xylomannans: effects on antiviral activity
Mercedes Pérez Recalde1, María J Carlucci, Miguel D Noseda
1Departamento de Química Orgánica-CIHIDECAR, CONICET-UBA, Facultad de Ciencias Exactas y Naturales, UBA, Pabellón 2, Ciudad Universitaria, 1428EGA Buenos Aires, Argentina.
Abstract:
The structures of two sulfated xylomannans extracted from the red alga Nemalion helminthoides were determined. These two fractions plus a sulfated mannan, isolated from the same alga and whose structure was previously reported, were subjected to chemical modification. The mannan was oversulfated with SO(3)-pyridine in dimethyl sulfoxide at 60 °C during two and three hours and the xylomannans were subjected to Smith degradation in order to eliminate xylose side-chains. Structural analysis of all derivatives was carried out by methylation analysis and (13)C NMR spectroscopy. Antiviral activity against herpes simplex virus type 1 and 2, and dengue virus type 2 of native and modified mannans and xylomannans was estimated. Anticoagulant effect of the active fractions was also determined.
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