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Updated: May 27, 2026

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Published on: January 28, 2014
Older patients with normal karyotype acute myeloid leukemia have a higher rate of genomic changes compared to young
Maya Koren-Michowitz1, Aiko Sato-Otsubo, Arnon Nagler
1Hematology/Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA. m.koren.michowitz@gmail.com
Abstract:
Older patients with AML have a worse outcome compared to young patients. To study for potential contributors to their poor prognosis, we compared two NK-AML cohorts, young (< 60 years old) and old (≥ 60 years old), via high density SNP array analysis. Older patients had more genomic changes (1.83 ± 0.23 vs. 1.16 ± 0.2, p=0.037) and a trend for a higher number of copy number neutral loss of heterozygosity (0.5 ± 0.2 vs. 0.24 ± 0.08, p=0.088) compared to young patients. We speculate that complex genomic changes in NK-AML may be a sign of an increase in genomic instability and an indicator of a worse prognosis.
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