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A new antifungal briarane diterpenoid from the gorgonian Junceella juncea Pallas
Y L N Murthy1, D Mallika, Abdul Rajack
1Organic Research Labs, Department of Organic Chemistry, Andhra University, Visakhapatnam 530 003, India. murthyyln@yahoo.co.in
Abstract:
A new 8-hydroxy briarane diterpenoid (compound 1) with antifungal activity was isolated along with known compounds (2-5) from the gorgonian coral Junceellajuncea. On the basis of spectroscopic data (1D and 2D NMR, MS), the structure of the compound 1 was established as (1S,2S,8S,9S,10S,11R,12R,14S,17R)-11,20-epoxy-14-(3-methylbutanoyl)-2,9,12-triacetoxy-8-hydroxybriar-5(16)-en-18,7-olide. Compound 1 exhibited significant activity against fungi (Aspergillus niger, Candida albicans and Penicillium notatum) but the other compounds (2-5) did not exhibit the activity against fungi.
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