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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization

Anke Tappe-Theodor1, Cristina E Constantin, Irmgard Tegeder

  • 1Pharmacology Institut, University of Heidelberg, Heidelberg, Germany Department of Physiology and Medical Physics, Division of Physiology, Innsbruck Medical University, Innsbruck, Austria Pharmazentrum Frankfurt, Klinikum der Goethe-Universität, Frankfurt am Main 60590, Germany Max-Delbrueck-Center for Molecular Medicine, Department of Neurosciences, Berlin 13125, Germany Spinal Cord Group, West Medical Building, University of Glasgow, University Avenue, Glasgow, UK.

Pain
|November 11, 2011
PubMed
Summary

Peripheral G protein-coupled receptor pathways modulate pain. Loss of G(q)/G₁₁ signaling in nociceptors reduces pain hypersensitivity and affects basal mechanical sensitivity, revealing a role in both pathological and tonic pain modulation.

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