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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

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Published on: May 25, 2020

Pattern electroretinogram progression in glaucoma suspects.

Lori M Ventura¹, Iuri Golubev, William J Feuer

¹Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Journal of Glaucoma

|November 11, 2011

Summary

Pattern electroretinogram (PERG) monitoring revealed significant retinal ganglion cell function loss in early glaucoma suspects. PERG showed higher sensitivity to progression than standard automated perimetry (SAP) in this longitudinal study.

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Area of Science:

Ophthalmology
Neuroscience
Medical Imaging

Background:

Early glaucoma detection is crucial for preventing vision loss.
Retinal ganglion cells (RGCs) are primary targets in glaucoma.
Longitudinal monitoring aids in understanding disease progression.

Purpose of the Study:

To prospectively assess progressive changes in RGC function using pattern electroretinogram (PERG).
To compare the sensitivity of PERG with standard automated perimetry (SAP) in detecting early glaucoma progression.

Main Methods:

Fifty-nine glaucoma suspects were monitored untreated for an average of 5.7 years.
PERG and SAP were performed biannually.
PERG signal and phase data were analyzed for progression slopes and signal-to-noise ratios (SNR).

Main Results:

PERG showed significant progression in amplitude/phase in 15-25% of eyes.
SAP indices (MD, PSD) showed progression in only 0-8% of eyes.
PERG demonstrated higher SNRs compared to SAP, indicating greater sensitivity.

Conclusions:

PERG effectively detects longitudinal decline in RGC function in early glaucoma suspects.
PERG is more sensitive than SAP in identifying early glaucomatous changes.
Further research is needed to confirm PERG's predictive value for visual dysfunction.