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Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

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NARWHAL, a primary analysis pipeline for NGS data.

R W W Brouwer1, M C G N van den Hout, F G Grosveld

  • 1Center for Biomics, Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands.

Bioinformatics (Oxford, England)
|November 11, 2011
PubMed
Summary
This summary is machine-generated.

The NARWHAL software pipeline automates Illumina sequencing data analysis with a flexible de-multiplexing tool and automated quality assessment. It offers faster processing and a simplified workflow for diverse sequencing applications.

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Area of Science:

  • Bioinformatics
  • Genomics
  • Computational Biology

Background:

  • Automated analysis of high-throughput sequencing data is crucial for genomic research.
  • Existing pipelines can be inflexible and computationally intensive.
  • The National Alliance for Research on the Waterfront (NARWHAL) project developed a new software pipeline.

Purpose of the Study:

  • To develop an automated software pipeline for primary analysis of Illumina sequencing data.
  • To improve the speed and flexibility of sequencing data processing.
  • To simplify the workflow for diverse sequencing applications.

Main Methods:

  • The NARWHAL pipeline integrates a novel de-multiplexing tool.
  • It utilizes open-source aligners and automated quality assessment modules.
  • A single, user-friendly sample-sheet configures the entire pipeline.

Main Results:

  • NARWHAL automates the primary analysis of Illumina sequencing data.
  • The pipeline creates a sample-oriented data structure for efficient management.
  • NARWHAL demonstrates superior speed performance compared to existing tools.

Conclusions:

  • The NARWHAL pipeline provides an efficient and automated solution for sequencing data analysis.
  • Its flexibility and speed make it suitable for various genomic applications.
  • This tool streamlines primary analysis, facilitating faster research insights.