Impact of cortical plasticity on patterns of suprathreshold activity in the cerebral cortex

There are many cellular and synaptic mechanisms of plasticity in the vertebrate cortex. How the patterns of suprathreshold spiking activity in a population of neurons change because of this plasticity, however, has hardly been subjected to experimental studies. Here, we measured how evoked patterns of suprathreshold spiking activity in a cortical network were modified by cortical plasticity with single-cell and single-spike resolution. To record patterns of activity in the rodent barrel cortex, we used optical methods to detect suprathreshold activity from up to 40 neurons simultaneously. Pairing of two inputs resulted in a long-lasting modification of the cortical responses evoked by one of the inputs. The results indicate that plasticity rules on the network level inherit properties from synaptic plasticity rules but are also determined by the functional synaptic architecture, as well as the computations carried out in cortical networks. The largest determinants of the modified cortical responses were those observed when inducing changes by pairing the two inputs. On the single-neuron level, the modified responses only weakly reflected those observed when pairing the two inputs for induction of plasticity. Despite the weak reflection on the cellular level, however, the modified patterns reflected the pairing patterns to the degree that a simple decoding mechanism-a linear separator-correctly discriminated the modified responses from other patterns of activity.