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Related Experiment Video

Updated: May 27, 2026

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes

Published on: June 10, 2021

Cellular reprogramming: recent advances in modeling neurological diseases.

Guo-Li Ming¹, Oliver Brüstle, Alysson Muotri

¹Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. gming1@jhmi.edu

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|November 11, 2011

Summary

Cellular reprogramming generates patient-specific neurons for studying neurological diseases. This technology offers new models for understanding disease mechanisms and developing targeted therapies for conditions like Alzheimer's disease.

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Area of Science:

Neuroscience
Stem Cell Biology
Genetics

Background:

Cellular reprogramming enables the generation of human neurons from skin fibroblasts.
Patient-derived neurons allow for in vitro investigation of neurological disease etiology.

Purpose of the Study:

To summarize innovative approaches in cellular reprogramming for modeling neurodevelopmental and neurodegenerative diseases.
To highlight the potential of patient-specific neurons in understanding disease mechanisms and developing therapies.

Main Methods:

Generation of human neurons from adult and neonatal fibroblasts via cellular reprogramming.
Utilizing patient-derived neuronal populations harboring specific genetic mutations.

Main Results:

Established methods for creating renewable sources of human neurons.
Demonstrated the utility of patient-derived neurons in modeling diseases like autism, schizophrenia, and Alzheimer's.

Conclusions:

Cellular reprogramming holds significant promise for advancing the understanding and treatment of neurological disorders.
Further research is needed to fully harness the therapeutic potential of this technology for neurological diseases.