Related Experiment Video
Updated: May 27, 2026

Use of Synaptic Zinc Histochemistry to Reveal Different Regions and Laminae in the Developing and Adult Brain
Published on: October 29, 2017
The neurophysiology and pathology of brain zinc
Stefano L Sensi1, Pierre Paoletti, Jae-Young Koh
1Department of Neuroscience and Imaging, Molecular Neurology Unit, CeSI-Center for Excellence on Aging, University "G. d'Annunzio," Chieti 66013, Italy. ssensi@uci.edu
Abstract:
Our understanding of the roles played by zinc in the physiological and pathological functioning of the brain is rapidly expanding. The increased availability of genetically modified animal models, selective zinc-sensitive fluorescent probes, and novel chelators is producing a remarkable body of exciting new data that clearly establishes this metal ion as a key modulator of intracellular and intercellular neuronal signaling. In this Mini-Symposium, we will review and discuss the most recent findings that link zinc to synaptic function as well as the injurious effects of zinc dyshomeostasis within the context of neuronal death associated with major human neurological disorders, including stroke, epilepsy, and Alzheimer's disease.
Related Concept Videos
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Gut-Brain Axis
Neuroplasticity
Ligand-Gated Ion Channel Receptor: Gating Mechanism

