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Updated: May 27, 2026

Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo

Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo

Published on: February 23, 2024

Biomaterials for craniofacial reconstruction.

Andreas Neumann¹, Kevin Kevenhoerster

¹Lukaskrankenhaus, HNO-Klinik, Neuss, Germany.

GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery

|November 11, 2011

Summary

This summary is machine-generated.

Biomaterials like titanium are used for skull reconstruction after injury or tumor removal. The choice of material depends on the specific defect, with ongoing research to improve properties for better patient outcomes.

Keywords:

biomaterials bone replacement craniofacial reconstruction osteosynthesis titanium

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Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Area of Science:

Biomaterials Science
Orthopedic Surgery
Craniofacial Reconstruction

Background:

Skull defects arise from trauma, malformations, or tumor resections, requiring biomaterials for reconstruction.
Current applications include osteosynthesis for fractures and defect filling, as well as functional and aesthetic augmentations.

Purpose of the Study:

To review biomaterials used in skull reconstruction.
To discuss the advantages and controversies of different materials, including titanium alloys and resorbable systems.
To highlight future directions in biomaterial development for craniofacial applications.

Main Methods:

Review of existing literature on biomaterials for bony defect reconstruction.
Analysis of properties such as biocompatibility, stability, and fitting for various materials.
Discussion of clinical applications and future research trends.

Main Results:

Titanium alloys offer advantages in biocompatibility and stability for osteosynthesis.
The necessity of removing asymptomatic implants remains controversial.
Resorbable systems are beneficial for pediatric patients, and no single optimal biomaterial exists for all indications.

Conclusions:

A wide range of biomaterials, including metals, ceramics, plastics, and composites, are available for skull reconstruction.
Future research focuses on enhancing surface interactions and biological properties.
Tissue-engineered bone is not yet a routine clinical option.