Endometrial hyperplasia: a five-year study

Because of the recent controversy concerning estrogen and endometrial cancer, we studied the possible potential precursor lesions of the endometrium, reviewing 263 patients hospitalized in a community teaching hospital. The estrogen hormonal status, either exogenously or endogenously produced, plays a large role in the histologic structure of the uterine endometrium and may lead to difficulty in determining the exact histologic diagnosis or its potential to progress to endometrial adenocarcinoma.