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Updated: May 27, 2026

Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation
Published on: December 5, 2025
[Long term oxygen therapy and mechanical ventilation for patients with COPD]
Toshiki Yokoyama1, Hiroshi Yamamoto, Keishi Kubo
1First Department of Internal Medicine, Shinshu University School of Medicine.
Long term oxygen therapy (LTOT) and non-invasive positive pressure ventilation (NPPV) are key non-drug treatments for chronic obstructive pulmonary disease (COPD). NPPV may enhance quality of life for COPD patients with hypercapnia during the chronic phase.
Area of Science:
- Pulmonary Medicine
- Respiratory Care
Context:
- Chronic obstructive pulmonary disease (COPD) management involves non-drug interventions.
- Long term oxygen therapy (LTOT) is recognized for improving COPD prognosis, especially in severe respiratory failure.
- Non-invasive positive pressure ventilation (NPPV) is effective for acute exacerbations, potentially avoiding intubation.
Purpose:
- To review the role of LTOT and NPPV in COPD management.
- To highlight the benefits of NPPV in the chronic phase of COPD for selected patients.
Summary:
- LTOT improves prognosis in severe COPD.
- NPPV is effective in acute COPD exacerbations.
- Carefully selected COPD patients with hypercapnia may benefit from NPPV in the chronic phase, improving quality of life.
Impact:
- Non-drug therapies like LTOT and NPPV are crucial components of comprehensive COPD care.
- NPPV offers a potential quality of life improvement strategy for specific chronic COPD patient subgroups.
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