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Studies on the determination and degradation of pyrimethamine in mammals
R Kumar1, P Kaushik, C B Sharma
1Department of Biosciences and Biotechnology, University of Roorkee, India.
Biomedical Chromatography : BMC
|July 1, 1990
Abstract:
Treatment of pyrimethamine with blood plasma in vitro yields a metabolite which is also produced when the drug is administered through intravenous injection in the rat. A thin layer liquid chromatographic method for quantitative and qualitative determination of pyrimethamine and its metabolite in plasma and biological tissues is described.