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Related Experiment Videos

Plasma osteocalcin concentrations in cattle under various pathophysiological conditions.

M J Davicco1, V Coxam, R Roux

  • 1Mineral Metabolism Unit, INRA Theix, Ceyrat, France.

Bone and Mineral
|August 1, 1990
PubMed
Summary

Plasma osteocalcin (BGP) concentrations vary in cattle, with highest levels in fetal calves and lowest in older cows. Parturition influences BGP, suggesting a role in bovine bone metabolism regulation.

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Area of Science:

  • Veterinary Medicine
  • Endocrinology
  • Bone Metabolism

Background:

  • Osteocalcin (BGP) is a bone-specific protein.
  • Its role in cattle bone metabolism requires further investigation.

Purpose of the Study:

  • To measure plasma osteocalcin (BGP) concentrations in cattle across different life stages and physiological states.
  • To investigate the relationship between BGP and other metabolic markers.
  • To assess BGP changes around parturition.

Main Methods:

  • Radioimmunoassay was used to quantify plasma osteocalcin (BGP) levels.
  • Samples were collected from fetal, newborn, adolescent, and adult cattle, including pregnant and lactating cows.
  • BGP concentrations were correlated with somatomedin C, 1,25(OH)2D, and calcium levels.

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Main Results:

  • Highest BGP concentrations were observed in fetal calves (62 +/- 3 nM), with the lowest in 9-year-old pregnant lactating cows (15 +/- 3 nM).
  • No significant correlation was found between plasma BGP and somatomedin C, 1,25(OH)2D, or calcium.
  • Parturition in normally calving cows led to a peak in BGP 3 days postpartum, returning to baseline within 10 days.
  • Hypocalcemic, paretic cows showed a transient BGP increase post-calving.

Conclusions:

  • Plasma osteocalcin (BGP) levels exhibit significant variation in cattle based on age and reproductive status.
  • BGP concentrations fluctuate around parturition, indicating a dynamic role in bovine bone metabolism.
  • Osteocalcin may be involved in the physiological regulation of bone metabolism in cattle.