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Related Experiment Videos

Adrenaline and nocturnal asthma.

J F Morrison1, C Teale, S B Pearson

  • 1Pulmonary Function Laboratory, Killingbeck Hospital, Leeds.

BMJ (Clinical Research Ed.)
|September 8, 1990
PubMed
Summary

The nocturnal fall in plasma adrenaline does not cause nocturnal asthma. Correcting this drop in adrenaline levels did not improve peak expiratory flow rate in asthmatic patients.

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Area of Science:

  • Pulmonary Medicine
  • Endocrinology

Background:

  • Nocturnal asthma is a common and distressing condition.
  • The role of plasma adrenaline in nocturnal asthma remains unclear.

Purpose of the Study:

  • To investigate if the natural decrease in plasma adrenaline during the night contributes to nocturnal asthma.

Main Methods:

  • A double-blind, placebo-controlled, cross-over study was conducted.
  • Plasma adrenaline levels were corrected in asthmatic subjects during the night.
  • The effect on peak expiratory flow rate was assessed before and after parasympathetic blockade with atropine.

Main Results:

  • Correcting the nocturnal fall in plasma adrenaline did not significantly alter peak expiratory flow rate.
  • This finding held true both before and after parasympathetic blockade.

Conclusions:

  • The nighttime decline in plasma adrenaline is not a causative factor in nocturnal asthma.
  • Interventions targeting this specific hormonal change are unlikely to alleviate nocturnal asthma symptoms.

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