Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Physiological Control of Respiration01:23

Physiological Control of Respiration

Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Cardiopulmonary Resuscitation II: ACLS Airway Management01:22

Cardiopulmonary Resuscitation II: ACLS Airway Management

Airway management is a key skill in emergency and critical care settings, as maintaining a clear airway is essential for adequate oxygenation and ventilation.Head Tilt-Chin Lift TechniqueThe head tilt-chin lift maneuver is an essential technique primarily used in patients without suspected cervical spine injuries. To perform this maneuver, one hand is placed on the patient’s forehead, and gentle pressure is applied backward to tilt the head. The fingertips of the other hand are positioned under...
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen01:16

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen

Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simulation-based optimisation to quantify heterogeneity of specific ventilation and perfusion in the lung by the Inspired Sinewave Test.

Scientific reports·2021
Same author

Tidal changes in PaO<sub>2</sub> and their relationship to cyclical lung recruitment/derecruitment in a porcine lung injury model.

British journal of anaesthesia·2019
Same author

First-in-human study of the safety and viability of intraocular robotic surgery.

Nature biomedical engineering·2018
Same author

A modification of the Bohr method to determine airways deadspace for non-uniform inspired gas tensions.

Physiological measurement·2017
Same author

Intravascular oxygen sensors with novel applications for bedside respiratory monitoring.

Anaesthesia·2017
Same author

Intra-breath arterial oxygen oscillations detected by a fast oxygen sensor in an animal model of acute respiratory distress syndrome.

British journal of anaesthesia·2015
Same journal

Variation in peri-operative management of GLP-1 receptor agonists among UK anaesthetists.

Anaesthesia·2026
Same journal

Management of major thoracic trauma: a narrative review.

Anaesthesia·2026
Same journal

Pulmonary artery catheters or central venous catheters for cardiac surgery: the PUMA Pilot randomised clinical trial.

Anaesthesia·2026
Same journal

Opioid-free vs. opioid-inclusive anaesthesia with or without regional anaesthesia for postoperative pain.

Anaesthesia·2026
Same journal

Optimal dose of intra-operative dexmedetomidine for postoperative delirium prevention: a reply.

Anaesthesia·2026
Same journal

Optimal dose of intra-operative dexmedetomidine for postoperative delirium prevention.

Anaesthesia·2026
See all related articles

Related Experiment Video

Updated: May 27, 2026

A Model to Simulate Clinically Relevant Hypoxia in Humans
09:54

A Model to Simulate Clinically Relevant Hypoxia in Humans

Published on: December 22, 2016

Simulating hypoxia and modelling the airway.

A D Farmery1

  • 1Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital and Tutor in Physiology, Wadham College, University of Oxford, Oxford, UK. andrew.farmery@nda.ox.ac.uk

Anaesthesia
|November 15, 2011
PubMed
Summary
This summary is machine-generated.

Airway obstruction during anesthesia causes rapid oxygen desaturation (hypoxemia). Mathematical modeling helps predict hypoxemia kinetics when experimental studies are not feasible, improving patient safety.

More Related Videos

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
07:56

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Published on: November 11, 2020

Related Experiment Videos

Last Updated: May 27, 2026

A Model to Simulate Clinically Relevant Hypoxia in Humans
09:54

A Model to Simulate Clinically Relevant Hypoxia in Humans

Published on: December 22, 2016

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
07:56

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Published on: November 11, 2020

Area of Science:

  • Anesthesiology
  • Critical Care Medicine
  • Physiological Modeling

Background:

  • Airway obstruction leading to hypoxemia is a significant risk in anesthesia and critical care.
  • Manual ventilation may not effectively correct hypoxemia caused by airway obstruction.
  • Experimental studies are often impractical, necessitating alternative investigation methods.

Purpose of the Study:

  • To explore the utility of mathematical and computer modeling for predicting hypoxemia kinetics following airway obstruction.
  • To provide insights into the physiological consequences of airway obstruction in a controlled, predictable manner.

Main Methods:

  • Development and application of high-fidelity mathematical and computer models.
  • Simulation of physiological responses to airway obstruction.
  • Analysis of hypoxemia development kinetics.

Main Results:

  • Mathematical and computer models can predict the consequences of airway obstruction with reasonable accuracy.
  • These models offer a valuable tool for understanding the complex event of airway obstruction.
  • Over 15 years, significant advancements have been made in high-fidelity modeling.

Conclusions:

  • Modeling provides a feasible approach to study the kinetics of hypoxemia due to airway obstruction.
  • Advanced computational models enhance understanding and management of airway obstruction complications.
  • This approach aids in improving patient safety in anesthesia and critical care.