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Related Concept Videos

Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
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Fibronectins Connect Cells with ECM

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General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
The ADP/ATP Carrier Protein01:42

The ADP/ATP Carrier Protein

ADP/ATP carrier or AAC protein is the most abundant carrier protein in the inner mitochondrial membrane. It transports large quantities of ADP and ATP, equivalent to the average human body weight, every day. Among other transporters, ACC protein is one of the best-studied members of the mitochondrial carrier protein family. The ADP/ATP carrier protein comprises two transmembrane helices connected to a loop and a single alpha-helix on the matrix side. It switches between two conformational...

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Related Experiment Video

Updated: May 27, 2026

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve
09:13

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

Fetuin-A: a multifunctional protein.

Katsuhito Mori1, Masanori Emoto, Masaaki Inaba

  • 1Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. ktmori@med.osaka-cu.ac.jp

Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
|November 15, 2011
PubMed
Summary
This summary is machine-generated.

Fetuin-A, also known as alpha-2-HS-glycoprotein, plays a key role in mammalian physiology, impacting vascular calcification, insulin resistance, and neurodegenerative diseases. Recent research highlights its diagnostic and therapeutic potential.

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Expression, Purification, Crystallization, and Enzyme Assays of Fumarylacetoacetate Hydrolase Domain-Containing Proteins
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Expression, Purification, Crystallization, and Enzyme Assays of Fumarylacetoacetate Hydrolase Domain-Containing Proteins

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Area of Science:

  • Biochemistry
  • Physiology
  • Molecular Biology

Background:

  • Fetuin, discovered in 1944, is now recognized as fetuin-A (alpha-2-HS-glycoprotein).
  • It is involved in numerous physiological and pathological processes.
  • Its significance in mammalian systems is increasingly appreciated.

Purpose of the Study:

  • To summarize recent publications on the structural and functional properties of fetuin-A.
  • To discuss the emerging diagnostic and therapeutic potential of fetuin-A.
  • To review the patent landscape surrounding fetuin-A.

Main Methods:

  • Literature review of recent publications on fetuin-A.
  • Analysis of fetuin-A's roles in various biological processes.
  • Examination of patent filings related to fetuin-A.

Main Results:

  • Fetuin-A is implicated in vascular calcification, bone metabolism, insulin resistance, protease activity, and keratinocyte migration.
  • It also plays a role in breast tumor cell signaling.
  • Fetuin-A is identified as a potential biomarker for neurodegenerative diseases.

Conclusions:

  • Fetuin-A is a multifunctional protein with significant implications in health and disease.
  • Its roles in diverse processes underscore its importance in mammalian physiology.
  • Fetuin-A presents promising opportunities for pharmaceutical development and therapeutic strategies.