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FGF and ROR2 receptor tyrosine kinase signaling in human skeletal development

Sigmar Stricker1, Stefan Mundlos

  • 1Development and Disease Group, Max Planck-Institute for Molecular Genetics, Berlin, Germany.

Current Topics in Developmental Biology
|November 15, 2011
PubMed

Insights

Skeletal malformations are common human developmental issues. This review details the roles of fibroblast growth factor receptors (FGFRs) and ROR2 tyrosine kinase in skeletal development and disease.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Skeletal malformations are frequent human developmental disturbances.
  • Receptor tyrosine kinases are crucial for embryonic development.
  • Fibroblast growth factor receptors (FGFRs) and ROR2 are key players in skeletal formation.

Purpose of the Study:

  • To review the involvement of FGFR signaling in human skeletal diseases.
  • To provide an update on the knowledge of ROR2 in skeletal development.

Main Methods:

  • Review of scientific literature.
  • Analysis of animal models for skeletal development.
  • Identification of mutations causing human skeletal syndromes.

Main Results:

  • FGFR signaling is critical for cranial, axial, and appendicular bone formation.
  • ROR2 tyrosine kinase has a complex and significant role in skeletal development.

Conclusions:

  • Understanding FGFR and ROR2 pathways is vital for addressing skeletal malformations.
  • Further research into these receptor tyrosine kinases will advance the treatment of skeletal disorders.

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