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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Related Experiment Video

Updated: May 27, 2026

Comparison of Two Representative Methods for Differentiation of Human Induced Pluripotent Stem Cells into Mesenchymal Stromal Cells

Comparison of Two Representative Methods for Differentiation of Human Induced Pluripotent Stem Cells into Mesenchymal Stromal Cells

Published on: October 20, 2023

Human embryonic stem cell-derived mesenchymal stromal cells.

Peiman Hematti¹

¹Department of Medicine, Division of Hematology/Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin 53705-2275, USA. pxh@medicine.wisc.edu

|November 15, 2011

Summary

This summary is machine-generated.

Mesenchymal stromal cells (MSCs) derived from human embryonic stem cells (ESCs) show promise for regenerative medicine. These ESC-derived MSCs possess potent immunomodulatory properties, similar to bone marrow MSCs, for potential therapeutic applications.

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Isolation and Characterization of Human Umbilical Cord-derived Mesenchymal Stem Cells from Preterm and Term Infants

Isolation and Characterization of Human Umbilical Cord-derived Mesenchymal Stem Cells from Preterm and Term Infants

Published on: January 26, 2019

Area of Science:

Stem cell biology
Regenerative medicine
Immunology

Background:

Mesenchymal stromal cells (MSCs) are valuable for regenerative therapy due to their differentiation and immunomodulatory potential.
MSCs can be isolated from various tissues and generated from human embryonic stem cells (ESCs).
ESC-derived MSCs offer a potential unlimited source for therapeutic applications.

Purpose of the Study:

To investigate the generation and characterization of MSCs from human ESCs.
To explore the potential of ESC-derived MSCs for bone and cartilage repair.
To assess the immunomodulatory properties of ESC-derived MSCs for clinical applications.

Main Methods:

Generation of MSCs from human ESCs.
In vitro and in vivo functional characterization of ESC-derived MSCs.
Comparison of immunomodulatory properties between ESC-derived MSCs and marrow-derived MSCs.

Main Results:

Human ESCs can be differentiated into MSCs with multipotent potential.
ESC-derived MSCs exhibit immunomodulatory properties comparable to adult MSCs.
ESC-derived MSCs show potential for bone and cartilage formation.

Conclusions:

Generation of MSCs from human ESCs is feasible and provides a valuable model for developmental biology.
ESC-derived MSCs possess significant immunomodulatory capacity, making them attractive for regenerative medicine.
ESC-derived MSCs hold promise for treating bone and cartilage defects and other conditions requiring immune modulation.